abstract：:This epidemiological study was undertaken to explore possible relationships among various haematological indices, prevalent ischaemic heart disease and platelet "function" as measured by two rather different methods. ADP-induced platelet impedance changes in whole blood were strongly associated with prevalent ischaemi...

journal_title：Thrombosis and haemostasis

authors： Sharp DS,Beswick AD,O'Brien JR,Renaud S,Yarnell JW,Elwood PC

更新日期：1990-10-22 00:00:00

abstract：:Platelets from cattle with the Chediak-Higashi syndrome (CHS) have a platelet dense granule deficiency. One hypothesis for the platelet dense granule deficiency is that the granule is simply not formed in CHS megakaryocytes (MK). Alternative hypotheses include that the granule is assembled in CHS MK but a functional a...

journal_title：Thrombosis and haemostasis

authors： Meyers K,Seachord C

更新日期：1990-10-22 00:00:00

abstract：:The generation of D-dimer was studied in the course of local thrombolytic therapy of peripheral arterial occlusions with low doses of recombinant human tissue-type plasminogen activator (rt-PA) in 7 patients. Intermittent local application of rt-PA resulted in a marked increase in D-dimer exceeding values usually seen...

journal_title：Thrombosis and haemostasis

authors： Koppensteiner R,Speiser W,Minar E,Ahmadi R,Ehringer H

更新日期：1990-10-22 00:00:00

abstract：:Ridogrel (6.3 x 10(-6) to 10(-4) M) inhibited contractions of isolated rat caudal arteries and rabbit femoral arteries caused by U-46619. The slope of an Arunlakshana-Schild plot (pA2-value: 3.4 x 10(-6) M) on the caudal artery was slightly higher than one (1.14). This effect was maximal within 20 min of incubation of...

journal_title：Thrombosis and haemostasis

authors： Janssens WJ,Cools FJ,Hoskens LA,Van Nueten JM

更新日期：1990-08-13 00:00:00

abstract：:We developed an ELISA test to measure the binding of plasma von Willebrand factor (vWF) to arterial microfibrils and compared this interaction to the binding of vWF to collagen under the same conditions. We found that vWF binds to microfibrils in a similar manner as it binds to collagen: the binding was independent of...

journal_title：Thrombosis and haemostasis

authors： Fauvel-Lafève F,Legrand YJ

更新日期：1990-08-13 00:00:00

abstract：:The effects on platelet function of a 5-day course of Ticlopidine (Tcl) have been studied in two groups of volunteers receiving different dosage schedules. Tcl had a relatively greater inhibitory effect on aggregation induced by ADP than by other agonists, and a greater effect, in contrast to that of an ADP receptor a...

journal_title：Thrombosis and haemostasis

authors： Hardisty RM,Powling MJ,Nokes TJ

更新日期：1990-08-13 00:00:00

abstract：:Platelets from a patient with an acquired hemorrhagic disorder had a severely impaired response to collagen, whereas platelet aggregation to other agonists and coagulations tests were normal. No abnormalities of the patient's platelet membrane glycoproteins (GP) were seen. Treatment of the patient with immunosuppressi...

journal_title：Thrombosis and haemostasis

authors： Deckmyn H,Chew SL,Vermylen J

更新日期：1990-08-13 00:00:00

abstract：:The influence of the sympathetic nervous system on platelet functions in vivo is still controversial. The aims of our study were to compare the response to various sympathetic stimuli in normal subjects and in patients with essential hypertension (HT) or peripheral vascular disease (PVD) and to evaluate any correlatio...

journal_title：Thrombosis and haemostasis

authors： Catalano M,Russo U,Belletti S,Colombo F,Belloni A,del Rosso G,Lombardi F,Libretti A

更新日期：1990-06-28 00:00:00

abstract：:The effects of mental stress (a colour word conflict test, CWT) and adrenaline infusions (0.1 and 0.4 nmol kg-1 min-1) on t-PA activity, t-PA antigen, PAI-1 activity and PAI-1 antigen were studied in 18 healthy male volunteers. Furthermore, the effects of metoprolol (200 mg/day during 1 week) or placebo (double-blind ...

journal_title：Thrombosis and haemostasis

authors： Larsson PT,Wiman B,Olsson G,Angelin B,Hjemdahl P

更新日期：1990-06-28 00:00:00

abstract：:The present studies measured bleeding times, without venous occlusion, in a series of patients, whose bleeding times (+ venostasis) consistently exceeded 20 min. During these tests, the amount of blood loss (expressed as mg/min) was also quantitated. To allow comparison, normal controls were studied before and followi...

journal_title：Thrombosis and haemostasis

authors： Zeigler ZR

更新日期：1990-06-28 00:00:00

abstract：:Parameters of the fibrinolytic system were studied in a primate model where the generation of thrombin was promoted in vivo. The procoagulant stimulus used was a combination of human factor Xa in combination with phosphatidylcholine/phosphatidylserine lipid vesicles (PCPS) as the source of coagulant active phospholipi...

journal_title：Thrombosis and haemostasis

authors： Giles AR,Nesheim ME,Herring SW,Hoogendoorn H,Stump DC,Heldebrant CM

更新日期：1990-06-28 00:00:00

abstract：:The structures of bovine and human vWF were compared by proteolysis with Staphylococcus aureus V8 protease and rattlesnake venom Protease I. Fragments were analyzed for chain composition, heparin binding, collagen binding, platelet agglutinating activity and recognition by a panel of monoclonal antibodies which reacte...

journal_title：Thrombosis and haemostasis

authors： Bakhshi MR,Kirby EP

更新日期：1990-06-28 00:00:00

abstract：:Antithrombotic potency of recombinant hirudins rHV2, rHV2-Lys47 and rHV2-Arg47 was studied in a model of experimental thrombosis induced by tissue factor in the rat. Venous thrombosis was induced by i.v. injection of 25 mg/kg tissue factor followed by stasis of the inferior vena cava. In this model natural recombinant...

journal_title：Thrombosis and haemostasis

authors： Freund M,Cazenave JP,Courtney M,Degryse E,Roitsch C,Bernat A,Delebassée D,Defreyn G,Maffrand JP

更新日期：1990-04-12 00:00:00

abstract：:Human endothelial cells isolated from umbilical cords were solubilized in Triton X-100 and examined by crossed immunoelectrophoresis using rabbit antiserum against endothelial cells. Endogenous labelling of the endothelial cell proteins with 14C-mannose followed by crossed immunoelectrophoresis and autoradiography rev...

journal_title：Thrombosis and haemostasis

authors： Børsum T

更新日期：1990-04-12 00:00:00

abstract：:Using a monoclonal antibody-based assay, we measured the fibrin degradation product release in the supernatant of plasma clots obtained before and after venous occlusion (VO) in 30 patients with definite or suspected vascular thrombosis (19 definite and 2 suspected deep vein thrombosis, 6 recurrent superficial thrombo...

journal_title：Thrombosis and haemostasis

authors： Gaussem P,Gandrille S,Molho-Sabatier P,Capron L,Fiessinger JN,Aiach M

更新日期：1990-02-19 00:00:00

abstract：:The terms glycoprotein IV (GPIV) and glycoprotein IIIb (GPIIIb) have been used interchangeably and reports in the literature have indicated this glycoprotein as having a molecular weight variously described as either 88,000 or 97,000, a fast anodal mobility on crossed electrophoresis and either 13 or less than 1 methi...

journal_title：Thrombosis and haemostasis

authors： Yamamoto N,de Romeuf C,Tandon NN,Jamieson GA

更新日期：1990-02-19 00:00:00

abstract：:Antithrombin III (ATIII) deficiency is one of the few known abnormalities of the coagulation system known to predispose to venous thromboembolism but its relation to arterial disease is not established. We describe two related patients with this disorder, both of whom suffered arterial thrombotic events, at an early a...

journal_title：Thrombosis and haemostasis

authors： Johnson EJ,Prentice CR,Parapia LA

更新日期：1990-02-19 00:00:00

abstract：:A recent report indicated that an arrow poison used by the native Indians of Rondonia, Brazil, to kill small animals was associated with profuse bleeding. The arrow poison was prepared from the bark of a tree, known locally as Tike-Uba. We have obtained bark and sap specimens from this tree and have characterized a po...

journal_title：Thrombosis and haemostasis

authors： Jacobs JW,Petroski C,Friedman PA,Simpson E

更新日期：1990-02-19 00:00:00

abstract：:Extrinsic coagulation pathway inhibitor may be an important regulator of haemostasis to prevent thrombosis after tissue damage. The functional activity of this inhibitor was determined using a chromogenic substrate assay, and compared to the activities of antithrombin, heparin cofactor II and protein C during the peri...

journal_title：Thrombosis and haemostasis

authors： Sandset PM,Høgevold HE,Lyberg T,Andersson TR,Abildgaard U

更新日期：1989-11-24 00:00:00

abstract：:Tissue plasminogen activator (tPA) activity in blood and blood plasma has been difficult to determine because it is unstable, especially in subjects with high levels of plasminogen activator inhibitor type 1 (PAI-1). We have attempted to stabilize the tPA activity by collecting 9 volumes of blood in 1 volume acidic ci...

journal_title：Thrombosis and haemostasis

authors： Rånby M,Sundell IB,Nilsson TK

更新日期：1989-11-24 00:00:00

abstract：:Incubation of platelet-rich plasma (PRP) with ouabain, an inhibitor of sodium/potassium ATPase (Na+/K+ ATPase), induced a significant rise in basal platelet intracellular calcium concentration [( Ca2+]i) when measured using fura 2. Ouabain induced an enhanced aggregation response to low doses of collagen in both PRP a...

journal_title：Thrombosis and haemostasis

authors： Lees AD,Wilson J,Orchard CH,Orchard MA

更新日期：1989-11-24 00:00:00

abstract：:Probands from 15 unrelated families with hereditary protein S deficiency type I, that is having a plasma total protein S concentration fifty percent of normal, were screened for abnormalities in their protein S genes by Southern analysis. Two probands were found to have a deviating DNA pattern with the restriction enz...

journal_title：Thrombosis and haemostasis

authors： Ploos van Amstel HK,Reitsma PH,Hamulyák K,de Die-Smulders CE,Mannucci PM,Bertina RM

更新日期：1989-11-24 00:00:00

abstract：:It has been experimentally shown that endotoxin induces a significant increase in the blood levels of a plasminogen activator inhibitor (PAI). We evaluated the effect of different doses of heparin (5 to 20 IU kg-1 h-1), antithrombin III (10 to 40 U kg-1 h-1 and 240 U/kg as bolus) and of a combination of the two on: 1)...

journal_title：Thrombosis and haemostasis

authors： Gómez C,Páramo JA,Colucci M,Rocha E

更新日期：1989-09-29 00:00:00

abstract：:Microangiopathy and disseminated platelet aggregation have been reported in thrombotic thrombocytopenic purpura (TTP) and pregnancy-induced hypertension (PIH). Since unusually large von Willebrand factor (vWF) multimers have been implicated in the evolvement of TTP, we analyzed factor VIII/vWF parameters in patients w...

journal_title：Thrombosis and haemostasis

authors： Brenner B,Zwang E,Bronshtein M,Seligsohn U

更新日期：1989-09-29 00:00:00

abstract：:A group of 90 hemophiliacs who had been regularly treated with non virus-inactivated factor VIII or IX concentrates were studied in 1983. At that time 50 patients were HIV-1-antibody positive, 6 additional seroconversions occurred until 1985. 26 of the 50 patients seropositive in 1983 are currently asymptomatic. 4 pat...

journal_title：Thrombosis and haemostasis

authors： Stain C,Pabinger-Fasching I,Guggenberger K,Köller U,Stain M,Hartl H,Heinz F,Mayerhofer S,Kyrle PA,Lechner K

更新日期：1989-06-30 00:00:00

abstract：:This article describes the results of a dietary intervention study performed in three different centers. In the study the effect of a diet enriched with fish on the coagulation tendency of blood was investigated. Two groups of 40 volunteers were given a dietary supplement consisting of 135 g of canned mackerel or meat...

journal_title：Thrombosis and haemostasis

authors： Muller AD,van Houwelingen AC,van Dam-Mieras MC,Bas BM,Hornstra G

更新日期：1989-06-30 00:00:00

abstract：:The aim of this study was to evaluate the existence of an additive effect between standard heparin and dDAVP in the enhancement of endogenous fibrinolysis. Eight healthy volunteers were studied in a randomized double blind placebo controlled cross-over trial. The volunteers were treated i.v. with dDAVP, 0.4 micrograms...

journal_title：Thrombosis and haemostasis

authors： Agnelli G,Levi M,Cosmi B,ten Cate JW,Nenci GG

更新日期：1989-06-30 00:00:00

abstract：:High physiological concentrations of plasma vasopressin (aVP) when achieved by infusion cause an increase in plasma factor VIII coagulant activity and shortening of the euglobulin clot lysis time (ECLT). To investigate the effects of aVP on components of the fibrinolytic pathway and on thrombin generation, 9 healthy v...

journal_title：Thrombosis and haemostasis

authors： Hariman H,Grant PJ,Hughes JR,Booth NA,Davies JA,Prentice CR

更新日期：1989-04-25 00:00:00

abstract：:In The Netherlands, a particular coagulometer method for prothrombin time (PT) determination with reduced sample and reagent volumes is used by 62% of the laboratories controlling oral anticoagulant therapy. This "micro-method" has been calibrated against the manual tilt-tube technique for PT determination by six Dutc...

journal_title：Thrombosis and haemostasis

authors： Peters RH,van den Besselaar AM,Olthuis FM

更新日期：1989-04-25 00:00:00

abstract：:Measurement of heparin ex vivo is usually with reference to standard curve prepared with a "spiked" normal human plasma pool (NHP). When the calibration curve was prepared by addition of heparin to whole blood before plasma separation, although the linear relationship was maintained the slope was increased in comparis...

journal_title：Thrombosis and haemostasis

authors： Melissari E,Thye C,Scully MF,Kakkar VV

更新日期：1989-04-25 00:00:00

abstract：:Tissue plasminogen activator labeled with radioactive iodine (125I-tPA) was immobilized on vascular prostheses chemically modified with a thin coating of water-insoluble surfactant, tridodecylmethylammonium chloride (TDMAC). Surfactant-treated Dacron, polytetrafluoroethylene (PTFE), silastic, polyethylene and polyuret...

journal_title：Thrombosis and haemostasis

authors： Harvey RA,Kim HC,Pincus J,Trooskin SZ,Wilcox JN,Greco RS

更新日期：1989-02-28 00:00:00

abstract：:Abnormal antithrombin III (AT III) was found in the plasma of a 31-year-old female who suffered from recurrent thrombotic episodes. Heparin cofactor activity was 28% of normal and undetectable when measured by inhibition of thrombin and factor Xa (F.Xa), while both progressive antithrombin and antifactor Xa activities...

journal_title：Thrombosis and haemostasis

authors： Okajima K,Ueyama H,Hashimoto Y,Sasaki Y,Matsumoto K,Okabe H,Inoue M,Araki S,Takatsuki K

更新日期：1989-02-28 00:00:00

abstract：:Reactivity of quinine- and quinidine-dependent antiplatelet antibodies has been compared in platelet-rich-plasma (PRP) from normal donors and from patients with von Willebrand's disease (vWd). One quinine-dependent antibody (Q.Ab) caused platelet aggregation and [14C] serotonin release with only 7 of 12 normal donors,...

journal_title：Thrombosis and haemostasis

authors： Pfueller SL,Bilston RA,Logan D,David R,Sloan IG,Firkin BG

更新日期：1989-02-28 00:00:00

abstract：:An assay system for protein C (PC) activity and PC-inhibitor in plasma was developed. The assay was based on: (1) binding of PC to wells of a microtiter plate coated with a murine monoclonal anti-PC antibody (C3) that did not interfere with the activity or activation of PC; (2) activation of immobilized PC with Protac...

journal_title：Thrombosis and haemostasis

authors： Geiger M,White TM,Griffin JH

更新日期：1989-02-28 00:00:00

abstract：:We have established a new analytical method which allows the characterization of von Willebrand factor (vWF) degradation fragments in minute amounts (10 microliters) of plasma, without the need for immunopurification of vWF. Plasma vWF was hydrolysed by S aureus V-8 protease (V-8 protease) and the cleaved fragments se...

journal_title：Thrombosis and haemostasis

authors： Takahashi Y,Kalafatis M,Girma JP,Meyer D

更新日期：1988-12-22 00:00:00

abstract：:To study the reversible complex formation between the plasma protein histidine-rich glycoprotein (HRG) and plasminogen, crossed immunoelectrophoresis of HRG was modified. In the modification, purified plasminogen was introduced into the gel of the first dimension electrophoresis. Two molecular forms of plasminogen, Gl...

journal_title：Thrombosis and haemostasis

authors： Kluft C,Los P

更新日期：1988-12-22 00:00:00

abstract：:Isolated rat hepatocytes possess per cell 4,500 high-affinity binding sites for thrombin with a Kd of 30-40 pM, and 2.8 X 10(5) low-affinity sites with a Kd of 30 nM. These binding sites are highly specific for thrombin. Half-maximal binding of 125I-labelled thrombin is achieved after 3 min at 37 degrees C and 7 min a...

journal_title：Thrombosis and haemostasis

authors： Weyer B,Petersen TE,Sonne O

更新日期：1988-12-22 00:00:00

abstract：:Antithrombin Milano is an unusual antithrombin variant, exhibiting an abnormal, fast moving component on crossed immunoelectrophoresis (in the absence of heparin). Antithrombin isolated from the propositus could be resolved into two peaks on anion-exchange chromatography; antithrombin Milano peak 1 of Mr approximately...

journal_title：Thrombosis and haemostasis

authors： Erdjument H,Lane DA,Ireland H,Di Marzo V,Panico M,Morris HR,Tripodi A,Mannucci PM

更新日期：1988-12-22 00:00:00

abstract：:Some classical hemophiliacs have a paradoxical hemostatic response to prothrombin complex concentrate (PCC). We hypothesized that vascular endothelial cells (EC) may contribute to this "factor VIII bypassing activity". When PCC were incubated with suspensions or monolayer cultures of EC, they acquired the ability to p...

journal_title：Thrombosis and haemostasis

authors： Teitel JM,Ni HY,Freedman JJ,Garvey MB

更新日期：1988-10-31 00:00:00

abstract：:The content of free-catecholamines in blood platelets is much higher than in plasma and platelet catecholamines must be taken up from plasma, since platelets lack the enzymes for catecholamine synthesis. There is some evidence that platelet catecholamine content under certain circumstances may be an integrated measure...

journal_title：Thrombosis and haemostasis

authors： Kjeldsen SE,Gjesdal K,Leren P,Eide IK

更新日期：1988-10-31 00:00:00